Mechanisms of antimicrobial resistance (AMR) and alternative approaches to overcome AMR.

Mechanisms of antimicrobial resistance (AMR) and alternative approaches to overcome AMR. Curr Drug Discov Technol. 2019 Mar 04;: Authors: Moo CL, Yang SK, Yusoff K, Ajat M, Thomas W, Abushelaibi A, Lim SH, Lai KS Abstract Antimicrobials are useful compounds intended to eradicate or stop the growth of harmful microorganisms. The sustained increase in the rates of antimicrobial resistance (AMR) worldwide is worrying and poses a major public health threat. Development of new antimicrobial agents is one of the critical approaches to overcome AMR. However, in the race towards developing alternative approaches to combat AMR, it appears that the scientific community is falling behind when pitched against the evolutionary capacity of multi-drug resistant (MDR) bacteria Although the "pioneering strategy" of discovering completely new drugs is a rational approach, the time and effort taken is considerable, the process of drug development could instead be expedited if efforts were concentrated on enhancing the efficacy of existing antimicrobials through: combination therapies;bacteriophage therapy; antimicrobial adjuvants therapy or the application of nano-technology. This review will briefly detail the causes and mechanisms of AMR as background, and then provide insights into novel, future emerging or evolving strategies that are currently being evaluated and which may be developed in the future to tackle the progression of AMR. PMID: ...
Source: Current Drug Discovery Technologies - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Discov Technol Source Type: research