Innate Immune Stimulation in Cancer Therapy.

Innate Immune Stimulation in Cancer Therapy. Hematol Oncol Clin North Am. 2019 Apr;33(2):215-231 Authors: Düwell P, Heidegger S, Kobold S Abstract The innate immune system has evolved as a first line of defense against invading pathogens and acts via classes of germline-encoded receptor systems to respond with proinflammatory cytokines. Innate immune cells, predominantly cells of the myeloid compartment, are capable of providing a potent basis for boosting adaptive immunity in malignant diseases. The authors review their current understanding of the molecular mechanisms whereby innate pattern recognition receptors participate in immunosurveillance of cancer cells. They discuss how innate effector mechanisms are currently being targeted pharmacologically and how improved understanding of the biology of these pathways is leading to novel immunotherapies of cancer. PMID: 30832996 [PubMed - in process]
Source: The Medical Clinics of North America - Category: General Medicine Authors: Tags: Hematol Oncol Clin North Am Source Type: research