68Ga-DOTATOC PET/CT Differentiates Meningioma From Dural Metastases.

68Ga-DOTATOC PET/CT Differentiates Meningioma From Dural Metastases.
Clin Nucl Med. 2019 Mar 01;:
Authors: Unterrainer M, Ruf V, Ilhan H, Vettermann FJ, Cyran CC, Niyazi M, Bartenstein P, Tonn JC, Albert NL
Abstract
A 77-year-old woman with history of breast cancer presented with 2 unclear dural contrast-enhancing lesions on MRI; differential diagnoses were breast cancer metastases and meningiomas. On Ga-DOTATOC PET/CT, the temporal lesion showed high uptake and was classified as meningioma, whereas the lesion at the falx showed barely any Ga-DOTATOC uptake uncharacteristic for meningioma and suggestive for a brain metastasis. After resection, histological specimens from the temporal lesion showed meningioma tissue with distinct SSTR2A expression, whereas the falx lesion revealed a breast cancer metastasis without significant SSTR2A expression. Therefore, Ga-DOTATOC PET represents a powerful imaging modality for the evaluation of unclear dural lesions.
PMID: 30829858 [PubMed - as supplied by publisher]

Source: Clinical Breast Cancer - February 28, 2019 Category: Cancer & Oncology Authors: Unterrainer M, Ruf V, Ilhan H, Vettermann FJ, Cyran CC, Niyazi M, Bartenstein P, Tonn JC, Albert NL Tags: Clin Nucl Med Source Type: research