IGF-1 Promotes Endocytosis of Alveolar Epithelial Cells through PI3K Signaling.

We report that IGF-1 increases endocytosis in a mouse alveolar epithelial cell line, MLE-12. The PI3K-Akt pathway is involved in this effect of IGF-1. Furthermore, IGF-1 can inhibit the production of interleukin-6 in lipopolysaccharide-stimulated AECs. We have found that IGF-1 can enhance endocytosis of AECs through the PI3K pathway and exhibit anti-inflammatory properties. These two observations suggest that IGF-1 is a potential mediator in the regulation of airway inflammation.
PMID: 30814071 [PubMed - in process]

Source: Annals of Clinical and Laboratory Science - December 31, 2018 Category: Laboratory Medicine Authors: Wang H, He J, Luo Y, Mu M, Guo S, Shen L, Qian Z, Fang Q, Song C Tags: Ann Clin Lab Sci Source Type: research