The C-terminus of the retinal homeobox (rax) gene product modulates transcription in a context-dependent manner.

Conclusions: The present data indicate that the C-terminus of Rax can function to repress or activate transcription in a context-dependent manner. These data support our hypothesis that the highly conserved OAR domain, in combination with other regulatory elements in the Rax C-terminus, coordinates Rax activity, perhaps through functional interaction with the N-terminal OP motif. Taken together, these data provide insight into the structural features that regulate Rax activity. PMID: 30820152 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/30820152?dopt=Abstract

Source: Molecular Vision - March 4, 2019 Category: Molecular Biology Tags: Mol Vis Source Type: research