Hepcidin cDNA evolution in vertebrates.

Hepcidin cDNA evolution in vertebrates. Vitam Horm. 2019;110:1-16 Authors: Boumaiza M, Abidi S Abstract Hepcidin, belonging to the β-defensin family, was isolated for the first time from plasma and human urine. It is a cationic peptide, rich in cysteine bound with four disulfide bridges, which plays a major role in innate immunity and iron homeostasis. Some vertebrate species have multiple hepcidin homolog genes and each contains only one copy that functions as an iron regulator except hepcidin sequences in the pigeon (Columba livia). The aim of this chapter is to investigate the molecular evolution of several hepcidin gene from searches of the literature and public genomic databases from 17 different species, all among the vertebrates. PMID: 30798806 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/30798806?dopt=Abstract

Source: Vitamins and Hormones - February 27, 2019 Category: Endocrinology Authors: Boumaiza M, Abidi S Tags: Vitam Horm Source Type: research