Surveillance and transportation of mitochondria in neurons.

Surveillance and transportation of mitochondria in neurons.
Curr Opin Neurobiol. 2019 Feb 18;57:87-93
Authors: Vanhauwaert R, Bharat V, Wang X
Abstract
Neurons need to allocate and sustain mitochondria to provide adequate energy and sufficient Ca2+-buffering capacity in each sub specialization of their extensive arborizations. Damaged mitochondria, which are highly deleterious to the neuron, must be rapidly repaired or eliminated, even when they are left at terminals extremely far away from the soma. The unique shape of neurons complicates the tasks of both transporting and clearing mitochondria. Errors in the underlying molecular regulations cause detrimental neurodegeneration. Here, we review the molecular machinery and regulatory mechanisms employed to transport, distribute, and clear mitochondria in neurons, and how these fundamental regulations are compromised in neurological disorders.
PMID: 30784981 [PubMed - as supplied by publisher]

Source: Current Opinion in Neurobiology - February 18, 2019 Category: Neurology Authors: Vanhauwaert R, Bharat V, Wang X Tags: Curr Opin Neurobiol Source Type: research