Blockade of PDGFR β circumvents resistance to MEK-JAK inhibition via intratumoral CD8+ T-cells infiltration in triple-negative breast cancer.

CONCLUSION: These findings reveal a novel regulatory role of JAK2-mediated PDGFRβ proteolysis and provide an example of a PDGFRβ-mediated resistance mechanism upon specific target inhibition in TNBC.
PMID: 30777101 [PubMed - in process]

Source: Clinical Breast Cancer - February 18, 2019 Category: Cancer & Oncology Authors: Kalimutho M, Sinha D, Mittal D, Srihari S, Nanayakkara D, Shafique S, Raninga P, Nag P, Parsons K, Khanna KK Tags: J Exp Clin Cancer Res Source Type: research