Molecular characterization of β-thalassemia intermedia in the West Bank, Palestine

ConclusionsHomozygosity for the mild β-globin gene IVS-I-6 allele was the major contributing factor for the TI phenotype among the study subjects. The role ofXmnI SNP and α-thalassemia mutations in ameliorating the TI phenotype was observed in few patients for each factor. The beta − 101 C >  T mutation was diagnosed in one patient in homozygote state for the first time in Palestine.
Source: BMC Hematology - Category: Hematology Source Type: research