Impact of two oral doses of 100,000  IU of vitamin D 3 in preschoolers with viral-induced asthma: a pilot randomised controlled trial

The objective was to ascertain the efficacy of high-dose vitamin D3 in increasing serum vitamin D in preschoolers with asthma and provide preliminary data on safety and efficacy outcomes.MethodsWe conducted a 7-month, triple-blind, randomised, placebo-controlled, pilot trial of children aged 1 –5 years with viral-induced asthma. Participants were allocated to receive two oral doses of 100,000 IU vitamin D3 (intervention) or identical placebo (control) 3.5  months apart, once in the fall and once in the winter. Serum 25-hydroxyvitamin D (25OHD) was measured by tandem mass spectrometry at baseline, 10 days, 3.5 months, 3.5 months + 10 days, and 7 months. The main outcome was the change in serum 25OHD from baseline (Δ25OHD) over time and at 3.5 and 7 months; other outcomes included the proportion of children with 25OHD ≥ 75 nmol/L, safety, and adverse event rates.ResultsChildren (N = 47) were randomised (intervention, 23; control, 24) in the fall. There was a significant adjusted group difference in the Δ25OHD (95% confidence interval) of 57.8 (47.3, 68.4) nmol/L,p 
Source: Trials - Category: Research Source Type: clinical trials

Related Links:

Photochem. Photobiol. Sci., 2019, Accepted Manuscript DOI: 10.1039/C9PP00372J, PaperDavide Ferrari, Giovanni Lombardi, Marta Strollo, Marina Pontillo, Andrea Motta, Massimo Locatelli The major source of vitamin D in humans is represented by the ultraviolet radiation which induces dermal synthesis of cholecalciferol, however, low vitamin D status is common in Europe even... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Photochem. Photobiol. Sci. latest articles - Category: Chemistry Authors: Source Type: research
Chem. Commun., 2019, Advance Article DOI: 10.1039/C9CC06545H, CommunicationPei-yu Li, Yong Chen, Chang-hui Chen, Yu Liu Amphiphilic multi-charged cyclodextrin (AMCD) and vitamin K (VK) co-assembly for heparin neutralization&vitamin K supplementation synergistic coagulation. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
Condition:   Breast Cancer Intervention:   Dietary Supplement: VITAMIN D Sponsor:   Institut du Cancer de Montpellier - Val d'Aurelle Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
We report a case of a neglected foreign body present in the bronchus of an adult for 23 years and treated as intermittent asthma. The diagnosis was revealed following the development of severe sepsis of a pulmonary origin. The foreign body was removed by rigid bronchoscopy, antibiotic therapy instituted and pre- and post-interventional respiratory physiotherapy carried out. Satisfactory progress was marked by the complete clearing of pulmonary suppuration, with only a small localized and asymptomatic focus of bronchial dilatation remaining. The persistence of chronic, unexplained respiratory complaints should prompt t...
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
Authors: Taytard J, Boizeau P, Alberti C, Beydon N Abstract INTRODUCTION: The reference technique to measure the diffusing capacity of the lung for carbon monoxide (DLco) is the single-breath method (sb). For patients unable to perform this method, the rebreathing method (rb) can be used. However, the clinical relevance of DLCOrb has not been evaluated. The aim of this study was to assess the feasibility of the rb method in children seen in a clinical setting and its relationships with sb method. SUBJECTS AND METHOD: We prospectively included children referred for 1) a suspected or confirmed interstitial lung d...
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and wine; probiotics and vitamins in prevention of stroke, age-related cognitive decline, and Alzheimer disease. Rev Neurol (Paris). 2019 Sep 11;: Authors: Román GC, Jackson RE, Gadhia R, Román AN, Reis J Abstract The mechanisms of action of the dietary components of the Mediterranean diet are reviewed in prevention of cardiovascular disease, stroke, age-associated cognitive decline and Alzheimer disease. A companion article provides a comprehensive revi...
Source: Revue Neurologique - Category: Neurology Tags: Rev Neurol (Paris) Source Type: research
Publication date: Available online 16 September 2019Source: Journal of Dental SciencesAuthor(s): Fang-yi Wu, Jeng-fen LiuAbstractBackground/purposeAsthma is a common, chronic disease that causes respiratory symptoms in children. Dental caries is also a common chronic disease in the pediatric population. Therefore, the aim of the present study was to investigate the correlation between asthma medications and dental caries among children in Taiwan.Materials and methodsThe Taiwan National Health Insurance Research Database was used in this retrospective cohort study to analyze the correlation between asthma and dental caries ...
Source: Journal of Dental Sciences - Category: Dentistry Source Type: research
VITAMIN B12 deficiency symptoms may appear if a person lacks the vitamin in their diet, and left untreated, the condition can lead to more serious health problems. One sign of the condition to look out for may become apparent when you eat.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
CONCLUSIONS: Therefore, P. ginseng is a potent hepatoprotector (vitamin-E to a lesser extent) and should be considered where liver damage is expected secondary to damaging medications; as cyclophosphamide. PMID: 31519295 [PubMed - in process]
Source: Complementary Therapies in Medicine - Category: Complementary Medicine Authors: Tags: Complement Ther Med Source Type: research
Environmental Science&TechnologyDOI: 10.1021/acs.est.9b02339
Source: Environmental Science and Technology - Category: Environmental Health Authors: Source Type: research
More News: Asthma | Children | Corticosteroid Therapy | Eyes | Hypercalcaemia | Research | Statistics | Vitamin D | Vitamin D3 | Vitamins