Investigational drug therapies currently in early stage clinical development for the treatment of clostridioides (clostridium) difficile infection.

Investigational drug therapies currently in early stage clinical development for the treatment of clostridioides (clostridium) difficile infection. Expert Opin Investig Drugs. 2019 Feb 12;: Authors: Tran MN, Kullar R, Goldstein EJ Abstract INTRODUCTION: Clostridioides (Clostridium) difficile Infection (CDI) is an urgent global threat causing ~500,000 infections annually in the United States of America (USA) and is associated with a 36% 30-day attributable mortality rate. Despite the availability of three therapeutic agents, CDI recurrence occurs in 20-40% of patients, with a 30-40% second recurrence rate in these patients. Consequently, there is a need for novel agents for treating CDI. Areas covered: We searched MEDLINE, PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov for agents in early stages of clinical development. These drugs include ACX-362E, DS-2969b, LFF 571, RBX2660, ribaxamase, ridinilazole that have advanced to at least phase 2 and several other drugs in phase 1 development. Expert Opinion: The challenge for these new agents is three-fold: 1) to have a novel approach such as a different target/mechanism of action; 2) be "significantly" better than existing agents in regard to "sustained clinical response"; or 3) be priced at a reasonable cost when it comes to market or perhaps all three. Their utility can only be proven by clinical trials. PMID: 30753786 [PubM...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research