One-pot synthesis of polypyrrole nanoparticles with tunable photothermal conversion and drug loading capacity

Publication date: Available online 8 February 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Bingqian Guo, Jiulong Zhao, Chenyao Wu, Yuting Zheng, Changqing Ye, Mingxian Huang, Shige WangAbstractWith an excellent near-infrared (NIR) light-responsive property, polypyrrole (PPy) nanoparticle has emerged as a promising NIR photothermal transducing agent for tumor photothermal therapy (PTT). However, the physicochemical characteristics of PPy can be affected by its morphology. Therefore, it is important to seek optimal processing parameter to optimize the application property of PPy-PVP NPs. Herein, we reported the PVP mediated one-pot synthesis of colloidal stable and biocompatible PPy nanoparticles (PPy-PVP NPs) for combined tumor photothermal-chemotherapy. The influence of molecular weight and PVP concentration on the spectroscopic characteristic, photothermal feature, drug loading performance, and antitumor efficiency of the resultant PPy-PVP NPs was systematically studied. By choosing PVP with a molecular weight of 360 kDa (concentration of 5 mg/mL) as the template and surface modifier during the synthesis, PPy-PVP NPs with spectroscopic characteristic, photothermal feature, drug loading performance, and antitumor efficiency. Findings in this study are anticipated to provide an in-depth understanding of the important character of surface engineering in the rational design and biomedical applications of PPy NPs.Graphical abstract
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research