Targeting the interplay between metabolism and epigenetics in cancer

Purpose of review Metabolic perturbation is a hallmark of cancer favoring tumor progression. It is now demonstrated that cell metabolism has an impact on gene expression through epigenetic modifications. In this review, we expose recent evidences of metabolic-driven epigenetic perturbations in cancer and subsequent therapeutic opportunities. Recent findings The intimate link between metabolism and epigenetics and its rewiring in carcinogenesis is a hot topic. Chromatin-modifying enzymes involved in the dynamics of methylation or acetylation require small metabolites as cofactors or substrates, thus orchestrating the integration between epigenetic and transcriptional states. Mutations in metabolic enzymes such as isocitrate dehydrogenase 1 and 2 cause the accumulation of metabolites that upset the balance of histone and DNA methylation, thus generating widespread deregulation of epigenetically controlled gene expression. Additionally, modifications of catalytic activity and subcellular localization of metabolic enzymes in cancer can impact on epigenetic modifications and gene expression programs to favor tumor progression. Summary The interplay between metabolism and epigenetics and its molecular characterization in cancer cells identifies potential targets for the development of new therapies.
Source: Current Opinion in Oncology - Category: Cancer & Oncology Tags: CANCER BIOLOGY: Edited by Pierre Hainaut Source Type: research

Related Links:

AM Abstract Adoptive transfer of T cells transgenic for tumor-reactive T-cell receptors (TCR) is an attractive immunotherapeutic approach. However, clinical translation is so far limited due to challenges in the identification of suitable target antigens as well as TCRs that are concurrent safe and efficient. Definition of key characteristics relevant for effective and specific tumor rejection is essential to improve current TCR-based adoptive T-cell immunotherapies. We here characterized in-depth two TCRs derived from the human leukocyte antigen (HLA)-mismatched allogeneic repertoire targeting two different myel...
Source: Nuklearmedizin - Category: Radiology Authors: Tags: Front Immunol Source Type: research
ConclusionsThe study recommend the development of a model to guide the integration of breast cancer prevention and early detection into palliative care
Source: International Journal of Africa Nursing Sciences - Category: African Health Source Type: research
Advances in nanophotonics could one day lead to new treatments for cancer, mental disorders More at https://www.nsf.gov/discoveries/disc_summ.jsp?cntn_id=298904&WT.mc_id=USNSF_1 This is a Research News item.
Source: NSF Discoveries - Category: Science Source Type: research
Publication date: Available online 18 July 2019Source: The American Journal of SurgeryAuthor(s): Brigid K. Killelea, Emily J. Gallagher, Sheldon M. Feldman, Elisa Port, Tari King, Susan K. Boolbol, Rebeca Franco, Kezhen Fei, Derek Le Roith, Nina A. BickellAbstractIntroductionAlthough breast cancer incidence is higher among white women, black women are more likely to have aggressive tumors with less favorable histology, and to have a worse prognosis. Obesity and alcohol consumption have been identified as two modifiable risk factors for breast cancer, while physical activity may offer protection. Little however is known abo...
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Publication date: Available online 18 July 2019Source: The American Journal of SurgeryAuthor(s): Laura H. Rosenberger, Samantha M. Thomas, Jennifer K. Plichta, Oluwadamilola M. Fayanju, Terry Hyslop, Rachel A. Greenup, E. Shelley HwangAbstractBackgroundSentinel lymph node biopsy has supplanted axillary lymph node dissection (ALND) in clinically node-negative breast cancer and select node-positive disease. We hypothesized a decreasing rate of both ALND and resident exposure over time.MethodsWe identified women with clinical Stage I-III breast cancer in the National Cancer Data Base (2004-2014). Adjusted multivariate logisti...
Source: The American Journal of Surgery - Category: Surgery Source Type: research
ConclusionsAmong breast cancer patients, nearly one-third exhibit clinical-pathological stage discordance. This high likelihood of discordance is important to consider for counseling and treatment planning.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Publication date: Available online 19 July 2019Source: European Journal of Surgical OncologyAuthor(s): John Tapper, Stefan Arver, Torbjörn Holm, Matteo Bottai, Mikael Machado, Ravi Jasuja, Anna Martling, Christian BuchliAbstractAimThe aim of this study is to analyze postoperative adverse events (AE) in relation to acute primary testicular failure after radiotherapy (RT) for rectal cancer.MethodThis relation was assessed in 104 men, included in a previous prospective cohort study of men treated with surgical resection of the rectum for rectal cancer stage I-III. Postoperative AE were graded according to Clavien-Dindo (...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
ConclusionExhaled breath condensate analysis combined with MS technique may become a valuable method for lung cancer screening and Dermcidin and S100A9 may serve as biomarkers for lung cancer diagnosis or prognosis.
Source: Lung - Category: Respiratory Medicine Source Type: research
Introduction: The gold standard for unresectable solid tumours and advanced forms of leukemia is represented by chemo-radiation. However, therapeutic options are limited and patients undergo systemic cytotoxicity. Vitamin D insufficiency is a widespread problem and its low serum levels are linked to higher cancer incidence. Previous studies showed a strong correlation between serum concentration of vitamin D and time of first treatment in chronic lymphocytic leukemia (CLL). Other studies demonstrated that vitamin D and its ipocalcemic analogue EB1089 are able to bypass radio-resistance in breast and lung cancer cell lines ...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Source Type: research
Introduction: The regular consumption of olive oil has associated with a protection against several diseases, including cancer. Epidemiological evidence indicate an inverse association between olive oil intake and bladder cancer risk. The phenolic fraction of olive oil plays a key role in this beneficial effect. Bladder cancer is one of the most common cancer in Europe, United States and Nord Africa. In particular, the transitional cell carcinoma histotype shows an aggressive behavior and the current therapies are ineffective.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Source Type: research
More News: Biology | Cancer | Cancer & Oncology | Genetics | Molecular Biology