GSE126188 Mismatch-repair signature mutations activate gene enhancers across human colorectal cancer epigenomes

Contributors : Alina R Saiakhova ; Stevephen Hung ; Peter C ScacheriSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensWe show that mismatch-repair (MMR) signature mutations can activate colorectal cancer (CRC)-specific enhancers, through analysis of enhancer DNA associated with the active enhancer histone mark H3K27ac. We demonstrate that MMR mutations activate enhancers using a xenograft metastasis model, where mutations are induced naturally via CRISPR/Cas9 inactivation of MLH1 prior to tumor cell injection.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research