Fluconazole induces genotoxicity in cultured human peripheral blood mononuclear cells via immunomodulation of TNF- α, IL-6, and IL-10: new challenges for safe therapeutic regimens.

CONCLUSIONS: Together, these findings suggest the need to rationalize the use of FNZ, especially if it is used for long periods or with concomitant pathologies requiring azole therapy that may increase FNZ's plasma concentration. PMID: 30721634 [PubMed - as supplied by publisher]
Source: Immunopharmacology and Immunotoxicology - Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research