GATA-4 regulates neuronal apoptosis after intracerebral hemorrhage via the NF- κB/Bax/Caspase-3 pathway both in vivo and in vitro.
In conclusion, the expression of GATA-4 was increased in the brain of rats after ICH. GATA-4 phosphorylation mediates the function of the protein in ICH-induced SBI. Neuronal apoptosis after ICH was mainly induced by NF-κB activation, which was promoted by GATA-4.
PMID: 30710529 [PubMed - as supplied by publisher]
Source: Experimental Neurology - Category: Neurology Authors: Xu H, Cao J, Xu J, Li H, Shen H, Li X, Wang Z, Wu J, Chen G Tags: Exp Neurol Source Type: research