MICROB-PREDICT -- € 15 million EU funded microbiome research project kicks off

(European Association for the Study of the Liver) An EU Horizon 2020-financed project investigating methods to better understand the role of the microbiome to help stratify patient health care and treatment of decompensated cirrhosis and ACLF officially commenced last month.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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CONCLUSIONS: DAA therapy for HCV in a pan-genotypic group of patients, many with advanced liver disease, was highly effective. Our outcomes correspond with existing trial and real-world data for similar treatment. DAA therapy and access need rapid upscaling in SA, especially targeting key populations at point of care. PMID: 32657680 [PubMed - as supplied by publisher]
Source: South African Medical Journal - Category: African Health Tags: S Afr Med J Source Type: research
Authors: Shah H, Yang TJ, Wudexi I, Solanki S, Patel S, Rajan D, Rodas A, Dajjani M, Chakinala RC, Shah P, Sarker K, Patel A, Aronow W Abstract BACKGROUND: Peptic ulcer disease (PUD) is more prevalent in cirrhotic patients and it has been associated with poor outcomes. However, there are no population-based studies from the United States (U.S.) that have investigated this association. Our study aims to estimate the incidence trends, predictors, and outcomes PUD patients with underlying cirrhosis. METHODS: We analyzed Nationwide Inpatient Sample (NIS) and Healthcare Cost and Utilization Project (HCUP) data for y...
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
Nonalcoholic fatty liver disease (NAFLD) is becoming a major health issue as obesity increases around the world. We studied the effect of a circadian locomotor output cycles kaput (CLOCK) mutant (ClkΔ19/Δ19) protein on hepatic lipid metabolism in C57BL/6 Clkwt/wt and apolipoprotein E–deficient (Apoe−/−) mice. Both ClkΔ19/Δ19 and ClkΔ19/Δ19 Apoe−/− mice developed a full spectrum of liver diseases (steatosis, steatohepatitis, cirrhosis, and hepatocellular carcinoma) recognized in human NAFLD when challenged with a Western diet, lipopolysaccharide, or CoCl2. We...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
AbstractObjectivesPrimary Objective: To determine if pre-exposure prophylaxis (PrEP) with 400mg hydroxychloroquine (HCQ), taken orally once daily reduces microbiologically confirmed COVID-19 among front line health care workers at high risk for SARS-CoV-2 exposure.Secondary Objectives: To compare the following between study arms: adverse events; symptomatic COVID-19; duration of symptomatic COVID-19; days hospitalized attributed to COVID-19; respiratory failure attributable to COVID-19 requiring i) non-invasive ventilation or ii) intubation/mechanical ventilation; mortality attributed to COVID-19, number of days unable to ...
Source: Trials - Category: Research Source Type: clinical trials
ConclusionsThe CUAs for CHC were found to apply to various HSUVs from different utility elicitation studies in the same health state. This variability in HSUVs has the potential to significantly affect ICER and ICER-based reimbursement decisions. A rigorous selection of HSUVs in CUAs to inform healthcare resource allocation is suggested for future studies of CUAs and for guideline development.
Source: Applied Health Economics and Health Policy - Category: Health Management Source Type: research
AbstractHepatic fibrosis and cirrhosis are chronic diseases affecting liver and a major health problem throughout the world. The hallmark of fibrosis and cirrhosis is inordinate synthesis and deposition of fibril forming collagens in the extracellular matrix of the liver leading to nodule formation and loss of normal architecture. Hepatic stellate cells play a crucial role in the pathogenesis and progression of liver fibrosis through secretion of several potent fibrogenic factors that trigger hepatocytes, portal fibrocytes, and bone marrow –derived fibroblasts to synthesize and deposit several connective tissue prote...
Source: Journal of Molecular Medicine - Category: Molecular Biology Source Type: research
Patients with liver cirrhosis develop changes in their brain function, and men often develop feminization with disease progression. However, the interaction between sex, microbiota and disease severity is unclear. We found that as disease progressed, microbiota in men that were different from women approached their composition with changes in specific microbes that are associated with male hormone metabolism.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research
Patients with acutely decompensated cirrhosis, who do not have organ failures (i.e., no acute-on-chronic liver failure [ACLF]) are considered as having acute decompensation (AD). The present study describes for the first time three different clinical courses of patients with AD after hospital admission. The first clinical course (pre-ACLF) includes patients who develop ACLF and has high probability of death. These patients are characterized by high-grade systemic inflammation. The second clinical course (unstable decompensated cirrhosis) includes patients requiring frequent hospitalizations unrelated with ACLF, show low-gr...
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research
Liver involvement has been commonly described in patients with cystic fibrosis (CF), especially during childhood and adolescence. According to the classical pathogenetic pathway, an impairment of bile composition may lead to intrahepatic biliary plugs, hepatocyte damage, cholestasis and ultimately biliary cirrhosis. Recent findings, showing high prevalence of microthrombi and endothelialitis at histology, without features of cirrhosis, suggested alternative mechanisms that contribute to liver involvement and development of portal hypertension [1,2].
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Case Report Source Type: research
November 2019 saw Cambridge, UK play host to the second Breath Biopsy Conference, a community-focused event aimed at sharing and supporting advancements in the collection and analysis of volatile organic compounds in exhaled breath. The event expanded upon the previous year ’s format, spanning two days and concluding with an expert panel discussion. Presentations covered detection, monitoring and precision medicine studies examining diseases including asthma, cirrhosis, cancer and tuberculosis. The meeting attracted representatives from diverse backgrounds, such as metabolomics, artificial intelligence, clinica...
Source: Journal of Breath Research - Category: Respiratory Medicine Authors: Source Type: research
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