FAM40A alters the cytoskeleton of podocytes in familial focal and segmental glomerulosclerosis by regulating F-actin and nephrin.

Conclusions: FAM40A played an important role in maintaining the normal morphology and function of MPs by stabilizing the cytoskeleton of MPs. Moreover, mutant FAM40A (p521M>T) was able to alter the morphology and cytoskeleton of the MPs, and to decrease the expression of nephrin, which may be the main factor contributing to FSGS. PMID: 30697267 [PubMed]

https://www.ncbi.nlm.nih.gov/pubmed/30697267?dopt=Abstract

Source: Archives of Medical Science - February 1, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research