MiR-212-5p exerts a protective effect in chronic obstructive pulmonary disease.

In this study, the expression level of miR-212-5p and miR-223 decreased significantly in COPD patients compared to healthy controls. In vitro experiments showed that cigarette smoke extract (CSE) induced NCI-H292 cell apoptosis and inhibited cell proliferation. Inflammation and COPD related genes were also upregulated by CSE, while miR-212-5p inhibited the overexpression of these genes. Furthermore, miR-212-5p promoted cell proliferation and inhibited IGFBP3 expression which was induced by CSE. The expression of p-Akt was also inhibited by CSE, while miR-212-5p significantly promoted the phosphorylation of Akt. In summary, our data suggest that miR-212-5p exerts a protective effect in COPD, and may serve as a prognostic biomarker and potential therapeutic target for COPD. PMID: 30695677 [PubMed - in process]
Source: Discovery Medicine - Category: Research Tags: Discov Med Source Type: research