Tau protein function: The mechanical exploration of axonal transport disorder caused by persistent pressure in dorsal root ganglia

ConclusionChronic compression of DRG and hypoxia caused phosphorylation of Tau in axons and inhibition of PSD ‐95, and the function of the synaptic glutamic acid vesicle is defective in the synapse. This process is crucial in the development and progression of axonal transport dysfunction induced by chronic DRG compression, and phosphorylation of Tau plays a substantial role in this process.

https://onlinelibrary.wiley.com/doi/abs/10.1002/mgg3.580?af=R

Source: Molecular Genetics & Genomic Medicine - January 29, 2019 Category: Genetics & Stem Cells Authors: Lei Zhang, Jun Fu, Xin ‐Hua Cheng, Li Tang Tags: ORIGINAL ARTICLE Source Type: research