The underlying regulated mechanisms of adipose differentiation and apoptosis of breast cells after weaning.

The underlying regulated mechanisms of adipose differentiation and apoptosis of breast cells after weaning.
Curr Protein Pept Sci. 2019 Jan 24;:
Authors: Dong Y, Gao W, Gao Z, Pu S, Xu X, Yang X, Zhang Y, Fang K, Li J, Yu W, Sun N, Hu L, Xu Q, Cheng Z, Gao Y
Abstract
Numerous experimental studies have demonstrated that a series of remodeling processes occurred in the adipose tissue during the weaning, such as the differentiation. Fibroblasts in the breast at weaning stage could re-differentiate into mature adipocytes. Many transcriptional factors were involved in these processes, especially the PPARγ, C/EBP, and SREBP1. There is cell apoptosis participating in the breast tissue degeneration and secretory epithelial cells losing during weaning. In addition, hormones, especially the estrogen and pituitary hormone, play a vital role in the whole reproductive processes. In this review, we mainly focus on the underlying regulated mechanisms of differentiation of adipose tissue and apoptosis of breast cell to provide a specific insight into the physiological changes during weaning.
PMID: 30678617 [PubMed - as supplied by publisher]

Source: Current Protein and Peptide Science - January 24, 2019 Category: Biochemistry Authors: Dong Y, Gao W, Gao Z, Pu S, Xu X, Yang X, Zhang Y, Fang K, Li J, Yu W, Sun N, Hu L, Xu Q, Cheng Z, Gao Y Tags: Curr Protein Pept Sci Source Type: research