Isolated choroid plexus involvement in a case of granulomatosis with polyangiitis negative for antineutrophil cytoplasmic antibodies (ANCA)

granulomatosis with polyangiitis (GPA, formerly Wegener's) is a systemic necrotizing vasculitis that predominantly involves respiratory tract and kidneys [1,2]. GPA usually presents with nervous system involvement in the later course, mainly affecting the peripheral nervous system [3]. Vasculitis has been reported up to 6% of GPA cases with central nervous system (CNS) involvement [2,4]. Detection of either anti-proteinase 3 (PR3)-ANCA or myeloperoxidase (MPO)-ANCA can support the diagnosis, but in some cases ANCA are not detected [3].

Source: Journal of the Neurological Sciences - January 26, 2019 Category: Neurology Authors: Margoni M, Barbareschi M, Rozzanigo U, Chioffi F, Paolazzi G, Marangoni S Tags: Letter to the Editor Source Type: research