Sudden cardiac death in a patient with LGI1 antibody-associated encephalitis
Anti-leucine-rich glioma-inactivated 1 limbic encephalitis (LGI1-LE) is one of the clinical syndromes associated with antibodies to voltage-gated potassium channels (VGKCs) [1]. In addition to the common LE symptoms such as cognitive impairment, psychiatric disturbances and seizures, patients with LGI1-LE manifest hyponatremia, and faciobrachial dystonic seizures (FBDS) in about 50% of cases. MRI abnormalities usually involve the medial temporal lobe and basal ganglia. LE typically affects middle-aged patients with a 2:1 male to female ratio and is rarely associated with cancer [1].
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Romana Rizzi, Francesco Fisicaro, Andrea Zangrandi, Enrico Ghidoni, Simone Baiardi, Moira Ragazzi, Piero Parchi Tags: Clinical letter Source Type: research
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