Adrenomedullin mediates pro-angiogenic and pro-inflammatory cytokines in asthma and COPD

ConclusionsThese data suggest that AM mediates the secretion of pro-angiogenic and pro-inflammatory cytokines in a cell-type and/or a disease-specific way, explaining its association with clinical outcomes in COPD.
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research

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Publication date: Available online 19 July 2019Source: SteroidsAuthor(s): Darina Hynes, Brian J. HarveyAbstractBasolateral membrane K+ channels play a key role in basal and agonist stimulated Cl- transport across airway epithelial cells by generating a favourable electrical driving force for Cl- efflux. The K+ channel sub-types and molecular mechanisms of regulation by hormones and secretagoues are still poorly understood. Here we have identified the type of K+ channels involved in cAMP and Ca2+ stimulated Cl- secretion and uncovered a novel anti-secretory effect of dexamethasone mediated by inhibition of basolateral membr...
Source: Steroids - Category: Drugs & Pharmacology Source Type: research
Authors: Gali B, Eyawo O, Hull MW, Samji H, Zhang W, Sereda P, Lima VD, McGrail K, Montaner JSG, Hogg RS, Moore D, COAST Study Team Abstract Objective: To characterize the incidence of select chronic comorbidities in the era of modern (pre-integrase inhibitor) highly active antiretroviral therapy (HAART) in British Columbia, Canada. Methods: We used data from the Comparative Outcomes And Service Utilization Trends (COAST) study, a population-based cohort study of people living with HIV (PLWH), to determine incidence rates of six key chronic diseases among PLWH receiving HAART in BC from 2000 to 2012. The selected d...
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
ConclusionOur findings indicate that suffering from asthma and/or COPD increases the risk of developing troublesome LBP, which highlights the importance to consider the overall health of people at risk of troublesome LBP and to take the multi-morbidity perspective into consideration. Future longitudinal studies are needed to confirm our findings.Graphic abstract These slides can be retrieved under Electronic Supplementary Material.
Source: European Spine Journal - Category: Orthopaedics Source Type: research
Occupational exposures are important, preventable causes of chronic obstructive pulmonary disease (COPD). Identification of COPD high-risk jobs is key to focus preventive strategies, but a definitive job-list is unavailable. We addressed this issue by evaluating the association of lifetime job-histories and lung function data in the population-based UK Biobank cohort, whose unprecedented sample size allowed analyses restricted to never-smokers to rule out the most important confounder, tobacco smoking. COPD was spirometrically defined as forced expiratory volume in 1 s/forced vital capacity ratio below the lower limit...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: COPD and smoking Original Articles: COPD Source Type: research
Publication date: June 2019Source: Global Heart, Volume 14, Issue 2Author(s): Joep J. van Oosterhout, Mina Hosseinipour, Adamson S. Muula, Alemayehu Amberbir, Emily Wroe, Josh Berman, Cecilia Maliwichi-Nyirenda, Victor Mwapasa, Amelia Crampin, Martha Makwero, Emmanuel Singogo, Satish Gopal, Ulrika Baker, Samuel Phiri, Stephen B. Gordon, Sheldon Tobe, Jonathan Chiwanda, Jones Masiye, John Parks, Collins MitamboAbstractAfrica is experiencing an increasing prevalence of noncommunicable diseases (NCD). However, few reliable data are available on their true burden, main risk factors, and economic impact that are needed to infor...
Source: Global Heart - Category: Cardiology Source Type: research
Conclusions: COPD was more frequently diagnosed among adults with WRA than those with non-WRA, and adults diagnosed with both WRA and COPD appear to have more severe adverse asthma outcomes than those with non-WRA and no COPD. PMID: 31303076 [PubMed - as supplied by publisher]
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
(Natural News) Antidepressants and antihistamines are among the most common types of medications people take, and they belong to a class of drugs known as anticholinergics. These drugs can treat a variety of health problems, including COPD, asthma, depression, dizziness, gastrointestinal problems, overactive bladder, and the symptoms of Parkinson’s. Although they can be effective, a...
Source: - Category: Consumer Health News Source Type: news
Clinical management of asthma and chronic obstructive pulmonary disease (COPD) has primarily relied on the use of beta 2 adrenergic receptor agonists (bronchodilators) and corticosteroids, and more recently, monoclonal antibody therapies (biologics) targeting specific cytokines and their functions. Although these approaches provide relief from exacerbations, questions remain on their long-term efficacy and safety. Furthermore, current therapeutics do not address progressive airway remodeling (AR), a key pathological feature of severe obstructive lung disease. Strikingly, agonists of the bitter taste receptors (TAS2Rs) deli...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Conclusion In spite of health care professionals  feeling comfortable with their counseling practices, the majority of patients reported dissatisfaction with the information they provided about medicine, and three out of four patients were making critical mistakes in the use of inhalers. More effort is warranted by health care professionals on pa tient education to limit critical mistakes.
Source: International Journal of Clinical Pharmacy - Category: Drugs & Pharmacology Source Type: research
PMID: 31291810 [PubMed - in process]
Source: Innate Immunity - Category: Allergy & Immunology Authors: Tags: Innate Immun Source Type: research
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