Brain-enriched MicroRNA-184 is downregulated in older adults with major depressive disorder: A translational study

Publication date: Available online 23 January 2019Source: Journal of Psychiatric ResearchAuthor(s): Ana Paula Mendes-Silva, Patricia Tiemi Fujimura, Jéssica Regina da Costa Silva, Antonio Lucio Teixeira, Erica Marciano Vieira, Pedro Henrique Gonçalves Guedes, Lucélia Scarabeli Silva Barroso, Mariana de Souza Nicolau, Jéssica Diniz Rodrigues Ferreira, Laiss Bertola, Eduardo de Souza Nicolau, Gesiane Thamire Tolentino-Araújo, Camila Moreira Silva Ferreira Berlezzi, Tamiris Sabrina Rodrigues, Luiza Diniz Ferreira Borges, Matheus de Souza Gomes, Laurence Rodrigues do Amaral, Ana Maria Bonetti, Carlos Ueira-Vieira, Breno Satler DinizAbstractChanges in microRNAs (miRNAs) expression have been described in major depressive disorder in young and middle-aged adults. However, no study has evaluated miRNA expression in older adults with major depression (or late-life depression [LLD]). Our primary aim was to evaluate the expression of miRNAs in subjects with LLD. We first evaluated the miRNA expression using next-generation sequencing (NGS) and then we validated the miRNAs found in NGS in an independent sample of LLD patients, using RT-qPCR. Drosophila melanogaster model was used to evaluate the impact of changes in miRNA expression on behavior. NGS analysis showed that hsa-miR-184 (log2foldchange = −4.21, p = 1.2 × 10−03) and hsa-miR-1-3p (log2foldchange = −3.45, p = 1.3 × 10−02) were significantly downregulated in LLD compared to the control group...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research