Predictive value of FHIT, p27, and pERK1/ERK2 in salivary gland carcinomas: a retrospective study
AbstractObjectivesThe aim of this study was to investigate the predictive value of the biomarkers FHIT, p27, and pERK1/ERK2 in salivary gland carcinomas.Material and methodsImmunohistochemical staining of FHIT, p27, and pERK1/ERK2 of 265 patients with salivary gland carcinomas was conducted, and associations with clinico-histopathological data, overall survival, and disease-specific survival were examined.ResultsExpression of FHIT (quick score 98.7 vs. 206.4) and p27 (QS 187.3 vs. 244.8) was significantly lower in carcinomas compared to non-tumor control tissue. Loss of FHIT frequently occurred in ACC (55.2%), SDC (68.2%), and SCC (100%). In the totality of tumors, loss of FHIT expression was found in 46.7% (106/227) and was significantly associated with advanced T stage and UICC stage, high-grade histology, loss of p27, PI3K, and survivin. FHIT positivity went along with significantly better overall and disease-specific survival. Negativity of p27 occurred in 28.7% (70/244) of tumors, particularly in SDC (54.4%) and SCC (50%). In the totality of tumors, p27 was associated with advanced patient age, high-grade histology, PI3K, survivin as well as better overall and disease-specific survival (p
Conclusion Most head and neck pathologies show a broad cellular heterogeneity making it difficult to achieve an accurate diagnosis and efficient treatment (Graf and Zavodszky, 2017; Lo Nigro et al., 2017). Single cell analysis of circadian omics (Lande-Diner et al., 2015; Abraham et al., 2018), may be a crucial tool needed in the future to fully understand the circadian control of head and neck diseases. It becomes more obvious that there is only a small genetic component but a largely unknown epigenetics and/or environmental component for most of the head and neck pathologies (Moosavi and Motevalizadeh Ardekani, 2016; He...
ConclusionsThis study showed that the NLR may serve as a useful prognosticator for a high risk of multiple recurrences in patients with ACC.
ConclusionsThis study shows, that NLR may serve as a useful prognosticator for a high risk of multiple recurrences in ACC patients.
Adenoid cystic carcinoma (ACC) is a rare entity of salivary gland cancer. Inflammatory and hematologic markers and their prognostic and predictive value have been intensively studied in several cancer entities. The aim of this study was to investigate the role of such markers in patients with ACC.
The androgen receptor (AR) is a nuclear steroid receptor that binds to testosterone and dihydrotestosterone and regulates the transcription of genes leading to cell growth, differentiation and survival. AR serves as an important oncogenic signal in prostate cancers and apocrine breast cancers. Salivary duct carcinoma (SDC) is a rare subtype of head and neck cancer that is defined by an apocrine phenotype, with AR positivity by immunohistochemistry (IHC) in up to 98% of cases . A recent clinical trial with leuprorelin acetate and bicalutamide has shown promising activity with an overall response rate of 42% in AR-positiv...
Salivary gland cancers comprise a wide histological spectrum with more than twenty different subtypes . In 2010, a new entity of salivary gland cancer was described by Sk álová et al., characterized by the presence of the ETV6-NTRK3 fusion gene . The histopathological appearance resembles secretory carcinoma of the breast, and both tumors share the ETV6-NTRK3 fusion gene, hence the proposed name was mammary analogue secretory carcinoma (MASC). In the updated 201 7 WHO classification, MASC is acknowledged and referred to as ‘secretory carcinoma’, to standardize nomenclature amongst different organ sites .
Salivary gland cancer is a rare disease that accounts for approximately 5% of all head and neck cancers and 0.3% of all human cancers [1 –3]. Salivary gland carcinoma arises in various regions of the major and minor salivary glands, presenting at least 24 different histological subtypes with different clinical features of metastasis and recurrence [4,5]. Distant metastases are relatively common in salivary gland carcinoma , and may be present at initial presentation or may emerge during the post-treatment period.
ConclusionsIn studied salivary gland cancers no PCR based prove mutations of BRAF V600 were detected. Further molecular analyses are necessary, in order to rapid molecular arrays for the identification of specific mutations, optimal for individualized targeted therapies.This article is protected by copyright. All rights reserved.
Conclusions ADT should be considered as a therapeutic option for unresectable advanced SDC.
Salivary gland cancers (SGCs) are uncommon diseases accounting for only 2 –6.5% of all head and neck cancers, and are characterized by considerable variability in their biology and natural history . Mucoepidermoid carcinoma (MEC), adenoid cystic carcinoma (ACC), and adenocarcinoma are the most frequent diagnoses, representing> 75% of all SGCs, although their frequency varies according to the site of origin (major vs minor salivary glands) . Prognosis among SGCs differs according to histology and grading: non-ACC and high-grade tumors are associated with a poorer prognosis compared with low-grade tumors [3 –5].