Synergistic activity of polymyxin B combined with vancomycin against carbapenem-resistant and polymyxin-resistant Acinetobacter baumannii: first in vitro study.

CONCLUSION: Our findings indicate that the PMB-VAN combination has a synergistic effect on A. baumannii, especially against PMB-resistant isolates. PMID: 30663954 [PubMed - as supplied by publisher]
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research

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Publication date: Available online 20 February 2020Source: Journal of Bioscience and BioengineeringAuthor(s): Linshu Jiao, Huibing Chi, Zhaoxin Lu, Chong Zhang, Shir Reen Chia, Pau Loke Show, Yang Tao, Fengxia Lul-Asparaginases have the potential to inhibit the formation of acrylamide, a harmful toxin formed during high temperature processing of food. A novel bacterium which produces l-asparaginase was screened. Type I l-asparaginase gene from Acinetobacter soli was cloned and expressed in Escherichia coli. The recombinant l-asparaginase had an activity of 42.0 IU mL−1 and showed no activity toward l-glutamine and d-...
Source: Journal of Bioscience and Bioengineering - Category: Biomedical Science Source Type: research
This study aimed to modify Muller-Hinton agar (MHA) to improve colistin diffusion in agar. METHODS: MHA was modified by reducing the agar concentration from 100% to 30% and supplementing with protamine. We tested 60 gram-negative clinical isolates of Pseudomonas aeruginosa (N=27) and Acinetobacter calcoaceticus-baumannii complex (N=33). Disk diffusion test results were interpreted based on minimum inhibitory concentrations determined by broth microdilution. RESULTS: The modified MHA yielded the best performance metrics, including 94.7% sensitivity, 100% specificity, and an area under the curve of 0.995 (95% confide...
Source: Annals of Laboratory Medicine - Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research
Acinetobacter baumannii is an emerging opportunistic pathogen that primarily infects critically ill patients in nosocomial settings. Because of its rapid acquisition of antibiotic resistance, infections caused by A. baumannii have become extremely difficult to treat, underlying the importance of identifying new antimicrobial targets for this pathogen. Manganese (Mn) is an essential nutrient metal required for a number of bacterial processes, including the response to oxidative stress. Here, we show that exogenous Mn can restore A. baumannii viability in the presence of reactive oxygen species (ROS). This restoration is not...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Molecular Pathogenesis Source Type: research
ConclusionsA. baumannii ST2 producing 16S rRNA methylase ArmA has been spreading in medical settings in Myanmar.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Conclusion: Intubated patients with multidrug-resistant, COS infections have a longer stay in ICU than non-COS patients. COS infections associated with bacteremia have high mortality.
Source: Journal of Global Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
This study aims to investigate the response of anaerobic microbial systems to cyanuric acid (CA) exposure; CA is toxic and possible carcinogen. First, the long-term exposure of mixed culture bacteria (i.e., municipal sludge) to low-strength wastewater containing 20 mg/L CA was conducted in an up-flow anaerobic staged reactor. Stable performance and sludge granulation were observed, and the microbial community structure showed the progression of genus Acinetobacter known as CA degrader. Second, batch-mode experiment was performed to examine the CA biodegradability at higher doses (up to 250 mg/L of CA) in the absence and pr...
Source: Journal of Advanced Research - Category: Research Source Type: research
Recent years have seen an unprecedented rise in the incidence of multidrug-resistant (MDR) Gram-negative bacteria (GNBs) such as Acinetobacter and Klebsiella species. In view of the shortage of novel drugs in the pipeline, alternative strategies to prevent, and treat infections by GNBs are urgently needed. Previously, we have reported that the Candida albicans hypha-regulated protein Hyr1 shares striking three-dimensional structural homology with cell surface proteins of Acinetobacter baumannii. Moreover, active vaccination with rHyr1p-N or passive immunization with anti-Hyr1p polyclonal antibody protects mice from Acineto...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Abstract Cefiderocol inhibited 97.5% of 478 Gram-negative isolates from cancer patients at ≤ 4 mg/L. It had potent activity against ESBL positive Enterobacteriaceae, carbapenem resistant Enterobacteriaceae, and non-fermenting Gram-negative bacilli including Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Acinetobacter spp. Amikacin, ceftazidime/avibactam and meropenem had appreciable activity against non-CRE Enterobacteriaceae No comparators were active against MDR P. aeruginosa. Only trimethoprim/sulfamethoxazole had appreciable activity against S. maltophilia Overall, cefiderocol was associated with...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
In this study, we evaluated the in vitro activity of KBP-7072 and comparator agents by CLSI M07 (2018) broth microdilution against 531 recent geographically diverse and/or molecularly characterized Acinetobacter baumannii-calcoaceticus species complex (A. baumannii) isolates from the United States, Europe, Asia-Pacific (excluding China), and Latin America. A. baumannii isolates included carbapenem-resistant, colistin-resistant, tetracycline-resistant, and extended-spectrum β-lactamase (ESBL)- and metallo-β-lactamase (MBL)-producing isolates. Overall, KBP-7072 (MIC50/90, 0.25/1 mg/L) was comparable in activity to ...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
The purpose of this study was evaluating the efficacy and safety of intravenous (IV) ampicillin–sulbactam plus nebulized colistin in the treatment of Ventilator-Associated Pneumonia (VAP) caused by MDR Acinetobacter (MDRA)in ICU patients as an alternative to IV plus nebulized colistin. In this single-blinded RCT, one group received IV colistin and another group IV ampicillin–sulbactam (16 and 12 patients from total 28 patients, respectively) for 14 days or since clinical response. Both groups received nebulized colistin by mesh nebulizer. There were no statistically significant differences between the 2 groups ...
Source: Iranian Journal of Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research
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