Abstract #96: Subthalamic Neural Closed-loop Deep Brain Stimulation for Bradykinesia in Parkinson's Disease

Introduction: Exaggerated neural synchrony in the beta band (13-30 Hz) in the subthalamic nucleus (STN) is a pathophysiological marker in Parkinson's disease (PD), the attenuation of which is related to the improvement in bradykinesia. Neural closed-loop deep brain stimulation (NclDBS) for PD has shown promise over open-loop (ol)DBS paradigms in several studies. Various groups have succeeded in using beta frequency signals to drive NclDBS and in some cases, it has proved more effective than olDBS with respect to motor disability scores (UPDRS-III).
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - Category: Neurology Authors: Source Type: research