Proceedings #8: Microstimulation Evoked Neuronal Activity in the Substantia Nigra pars reticulata in Anesthetized Rats

The Substantia Nigra pars reticulata (SNr) is a promising target for deep brain stimulation (DBS) to treat the gait and postural disturbances in Parkinson ’s Disease (PD). The effects of DBS in subregions of the SNr on the treatment of gait and postural disturbances in PD is not clear. We recorded neural activity in subregions of SNr using tungsten microwire electrodes in anesthetized rats and hypothesized that changes in coherence spectra between n eighboring microelectrode recordings correlated with electrode position within subregions of the SNr, i.e., lateral SNr and medial SNr.

Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: Hanyan Li, George C. McConnell Source Type: research