Candidemia in an Irish intensive care unit (ICU) setting between 2004 and 2018 reflects increased incidence of Candida glabrata

Publication date: Available online 19 January 2019Source: Journal of Hospital InfectionAuthor(s): Phelim Ryan, Catherine Motherway, James Powell, Ahmed Elsaka, Ambreen Ali Sheikh, Azhar Jahangir, Nuala H. O’Connell, Colum P. DunneSummaryThe cumulative incidence of candidemia in an Irish Intensive Care Unit (ICU) setting between January 2004 and August 2018 was 17/1000 ICU admissions. Candida albicans was responsible for 55% (n=41). C. glabrata (n=21: 28%) was the next most prevalent species; identified most frequently since 2012. C. glabrata was associated with a higher mortality rate (57%) than C. albicans (29%). All isolates were susceptible to caspofungin (0.05 μg/ml). Notably, 37% of C. glabrata isolates were fluconazole resistant, with 13% resistant to amphotericin B, highlighting need for prudent antifungal stewardship to impede development of multidrug-resistant C. glabrata in the ICU setting.
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research