Quinoline-derivative coordination compounds as potential applications to antibacterial and antineoplasic drugs

Publication date: Available online 16 January 2019Source: Materials Science and Engineering: CAuthor(s): Camila dos Santos Chagas, Fernando L.A. Fonseca, Izilda A. BagatinAbstractQuinoline-derivative coordination compounds were synthesized with Zn(II), Al(III), Cu(II), Ru(II) producing 1–4 compounds using 5-nitro-8-hydroxyquinoline and 5–8 compounds using 5-chloro-8-hydroxyquinoline. These coordination compounds were characterized by elemental analysis and 1H NMR, IR, UV–vis and fluorescence spectroscopies, representing the coherent data matched all compounds. Myelotoxicity data, as well as the biochemical data, depicted the compounds have low cytotoxicity towards the blood cells. All coordination compounds displayed slight antimicrobial activity against E. coli, S. aureus, P. aeruginosa and E. faecalis; [RuCl(NO)(5-chloro-8-oxyquinoline)2] compound (8) represent the best result to inhibitions of Gram-positive and Gram-negative bacteria. Antineoplasic action depicted the [Ru(NO)(5-nitro-8-oxyquinoline)2Cl] compound (4) as a potential chemotherapeutic agent against MCF-7 (a breast cancer cell line), compared to cisplatin (Platistine® CS) and cyclophosphamide (Genuxal®) drugs.Graphical abstractAntineoplasic action depicted the [Ru(NO)(5-nitro-8-oxyquinoline)2Cl] complex (4) as potential chemotherapeutic against MCF-7 (a breast cancer cell line), comparing to cisplatin (Platistine® CS).

Source: Materials Science and Engineering: C - January 17, 2019 Category: Materials Science Source Type: research