Duodenal-jejunal lining increases postprandial unconjugated bile acid responses and disrupts the bile acid-FXR-FGF19 axis in humans

Background and aims.Placement of the duodenal-jejunal bypass liner (DJBL) leads to rapid weight loss and restoration of insulin sensitivity in a similar fashion to bariatric surgery. Increased systemic bile acid levels are candidate effectors for these effects through postprandial activation of their receptors TGR5 and FXR. We aimed to quantify postprandial bile acid, GLP-1 and FGF19 responses and assess their temporal relation to the weight loss and metabolic and hormonal changes seen after DJBL placement.

Source: Metabolism - Clinical and Experimental - January 15, 2019 Category: Biomedical Science Authors: F. Samuel van Nierop, C. de Jonge, W. Kulik, Nicole Bouvy, Frank G. Schaap, Steven W. Olde Damink, Sander Rensen, Johannes A. Romijn, Jan Willem M. Greve, Maarten R. Soeters Source Type: research