Laparoscopic surgery may decrease the risk of clinical anastomotic leakage and a nomogram to predict anastomotic leakage after anterior resection for rectal cancer

ConclusionsA protective diverting stoma and laparoscopic surgery significantly decrease the risk of anastomotic leakage. Our nomogram was a useful tool for precise prediction of anastomotic leakage after anterior resection for rectal cancer.
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research

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Publication date: Available online 16 October 2019Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): V. Arpudhamary, S. Priya, Muhammed A.P. Manzoor, D. Mubarakali, S. HemalathaAbstractCancer is a group of diseases characterized by the rapid creation of abnormal cells. Cancer is one of the leading causes of death in humans, affecting millions of people per year. Cembranoids are carbocyclic diterpenes composed of 14-membered ring, mainly present in the genera Nicotiana and Pinus in plants, and soft coral and other organisms. Cembranoids are cytotoxic and inhibit phospholipid metabolism. The present study is focus...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
Publication date: Available online 16 October 2019Source: Molecular and Cellular ProbesAuthor(s): Fengwei Nan, Guibo Sun, Weijie Xie, Tianyuan Ye, Xiao Sun, Ping Zhou, Xi Dong, Jiafu Sun, Mengren Zhang, Xiaobo SunAbstractDiabetic encephalopathy is a severe diabetic complication characterized by cognitive dysfunction and neuropsychiatric disability. Methylglyoxal (MGO), a highly reactive metabolite of hyperglycemia, serves as a major precursor of advanced glycation end products that play key roles in diabetic complications. Ginsenoside Rb1 (abbreviated as Rb1) has received extensive attention due to its potential therapeuti...
Source: Molecular and Cellular Probes - Category: Molecular Biology Source Type: research
In this study, 3D Comparative Molecular Field Analysis (CoMFA) and Comparative Molecular Similarity Indices Analysis (CoMSIA) were employed to construct quantitative structure-activity relationship (QSAR) models of a series of niacinamide analogues as antiandrogens. The obtained models have good reliability and predictivity. In addition, the contour maps from the models can intuitively aid to understand the vital structural characteristics of niacinamides related with the AR antagonistic activities. Our study provides important guidance for the rational design and screening of highly potential active antiandrogens.
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
CONCLUSION: The results of the Keynote-048 study have already led to the approval of pembrolizumab in the first line for platin-sensitive HNSCC in the USA and the expected approval in Europe will presumably change the therapeutic landscape in the long term. In the future, effective therapies for patients without a response to programmed cell death 1 (PD-1)/PD-L1 inhibition will be needed. PMID: 31612261 [PubMed - as supplied by publisher]
Source: HNO - Category: ENT & OMF Tags: HNO Source Type: research
Publication date: Available online 16 October 2019Source: Chemico-Biological InteractionsAuthor(s): Yasmeen M. Attia, Dina M. El-Kersh, Reham A. Ammar, Aliaa Adel, Aya Khalil, Hoda Walid, Kirullos Eskander, Mohamed Hamdy, Nada Reda, Nour Elhoda Mohsen, Ghada M. Al-Toukhy, Mohamed Tarek Mansour, Mohamed M. ElmazarAbstractTreatment of breast cancer by paclitaxel (PAX) often encounters therapeutic failure most likely caused by innate/acquired resistance. Cancer stem cells (CSCs) and multidrug resistance complex (MDR-1 or P-glycoprotein) overexpression are main mechanisms implicated in chemoresistance. Increased aldehyde dehro...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
In this study, the levels of radioactivity in the muscle, liver, gonad, and gill tissues of the Whiting fish caught from Rize coast of the Black Sea during the winter season in 2017 were determined using gamma spectrometry. Data obtained from the fish showed that the mean activity concentrations in all tissues for males were found to be 4.57 Bq kg−1 for 226Ra, 2.79 Bq kg−1 for 232Th, 308.46 Bq kg−1 for 40K, and 3.38 Bq kg−1 for 137Cs, respectively. The mean activity concentrations in all tissues for females were found to be 2.56 Bq kg−1 for 226Ra, 2.28 Bq kg−1 for 232Th, 277.90 Bq kg&min...
Source: Microchemical Journal - Category: Chemistry Source Type: research
Publication date: Available online 16 October 2019Source: Inorganica Chimica ActaAuthor(s): Leila Tabrizi, Bachir Zouchoune, Abdallah ZaiterAbstractThe new gold(III), palladium(II), and platinum(II) complexes with 3-((4-nitrophenyl)thio)phenylcyanamide (HL) and 2,2′-bipyridine (bpy) ligands of formula [M(bpy)LCl] (M = Pd(II),1, Pt(II), 2) or [Au(bpy)LCl]Cl, 3, have been synthesized and fully characterized. The cytotoxicity of free ligands and complexes 1-3 were evaluated against HT-29 (colorectal adenocarcinoma), MCF-7 (breast), and HeLa (human squamous cervical adenocarcinoma) cancer cell lines along with MRC-5 non-...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
This study examines singlet... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Phys. Chem. Chem. Phys. latest articles - Category: Chemistry Authors: Source Type: research
Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9CC07515A, CommunicationXin Lin, Lifang Gao, Jian-Hua Wang, Xuwei Chen An array sensing platform exploiting phenyl boronic acid-functionalized pyrene amphiphilie/surfactant assemblies is constructed for glycoprotein discrimination, achieving a discrimination sensitivity of 50 nM. Gastric cancer cell lines of various differentiation... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
In this study, we constructed bioconjugates of targeting immune checkpoint B7 −H3 antibody and chlorin e6 to treat non-small cell lung cancer under the guidance of spectroscopic photoacoustic and fluorescence imaging.... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
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