Thymic inflammatory pseudotumor with multilocular thymic cyst caused by immunoglobulin G4 ‐related disease

A 44 ‐year‐old man was referred to our hospital after an anterior mediastinal tumor was noted on computed tomography during follow‐up observation after left testicular seminoma resection. Chest computed tomography revealed an enhanced mass measuring 33 x 16 x 15 mm at the anterior mediastinum. Ches t magnetic resonance imaging revealed high signal intensity on T2‐weighted imaging, and F18 fluorodeoxyglucose‐positron emission tomography showed a maximum standardized uptake of 12.45. Laboratory tests revealed no elevated tumor markers, except for mildly elevated interleukin‐2. Based on these results, complete resection was performed under suspicion of a malignant tumor, mediasti nal metastasis of seminoma, or malignant lymphoma. An extended thymectomy with partial merger pericardial resection was performed using a subxiphoid approach. Small nodules and multiple thymic cysts were observed the thymus in addition to the main mass. Microscopic examination of the tumor revealed fibrosis, lymphocyte infiltration with lymphoid follicular hyperplasia, and hyperplasia of the thymus. Numerous immunoglobulin G4 (IgG4)‐positive plasma cells were found on immunohistochemical staining. The ratio of IgG4 to total IgG was approximately 60%. We ultimately diagnosed the patient with a thymic inflammatory pseudotumor with multilocular cyst caused by IgG4‐related disease.
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: CASE REPORT Source Type: research