Early increase of CSF sTREM2 in Alzheimer ’s disease is associated with tau related-neurodegeneration but not with amyloid-β pathology

TREM2 is a transmembrane receptor that is predominantly expressed by microglia in the central nervous system. Rare variants in the TREM2 gene increase the risk for late-onset Alzheimer ’s disease (AD). Soluble TRE...

Source: Molecular Neurodegeneration - January 10, 2019 Category: Neurology Authors: Marc Su árez-Calvet, Estrella Morenas-Rodríguez, Gernot Kleinberger, Kai Schlepckow, Miguel Ángel Araque Caballero, Nicolai Franzmeier, Anja Capell, Katrin Fellerer, Brigitte Nuscher, Erden Eren, Johannes Levin, Yuetiva Deming, Laura Piccio, Celeste M. Tags: Research article Source Type: research