Sub-picomolar quantification of PTH1-34 in plasma by UHPLC-MS/MS after subcutaneous injection of teriparatide and identification of PTH1-33, its degradation product

This study emphasized the importance of switching from immunoassays to mass spectrometry when measuring bioactive peptides prompt to proteolysis into fragments that may exhibit altered bioactivity and duration of action.
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research