Use of antibiotic following kidney transplantation does not prevent virus infection

(The JAMA Network Journals) Among kidney transplant recipients, a 3-month course of the antibiotic levofloxacin following transplantation did not prevent the major complication known as BK virus from appearing in the urine. The intervention was associated with an increased risk of adverse events such as bacterial resistance, according to a study appearing in JAMA. The study is being released to coincide with its presentation at the American Society of Nephrology's annual Kidney Week meeting.
Source: EurekAlert! - Medicine and Health - Category: Global & Universal Source Type: news

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Abstract OBJECTIVES: BK virus is a polyomavirus that can cause nephropathy and graft loss after kidney transplant. The aim of our study was to screen the BK viremia prevalence, to understand the value of the inter-vention for BK virus nephropathy, and to determine the risk factors associated with BK viremia after kidney transplant in our center. MATERIALS AND METHODS: Our retrospective cross-sectional study included 91 adult kidney transplant recipients who were seen between 2015 and 2017 and who had follow-up from 1 month to over 2 years. BK viremia was evaluated by use of plasma quantitative polymerase chai...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - Category: Transplant Surgery Authors: Tags: Exp Clin Transplant Source Type: research
This study was approved by the ethics committee of Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China and the Review Board exempted the requirement for written informed consent because this retrospective study only focused on bacteria and did not affect the patients. Bacterial Strains and Growth Condition The clinical strain E. coli RJ904 was obtained from the blood specimen of a hospitalized patient in Shanghai, China (Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University) in 2005. Ceftazidime was used for the medication. The patient’s condition improved after the trea...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
This study was approved by our local ethical review committee in compliance with the declaration of Helsinki. Informed and written consent was obtained from all patients (Ethic Committee Charité University Medicine, Berlin, Germany, EA2/028/13). The study cohort consisted of 7 kidney transplant recipients with sustained BKV reactivation (Table 1). The HLA typing for each patient and donor is summarized in Figure 1. TABLE 1 Table 1. Characteristics of patients with BKV reactivation. FIGURE 1 Figure 1. Recipient and donor HLA type. HLA type of the patients and their kidney donors. Black square in...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusion: The results of this study suggested that, although saliva excretes more BKPyV than blood, there is no reliable correlation between salivary shedding and blood viremia, showing two independent compartments of viral replication.
Source: Journal of Applied Oral Science - Category: Dentistry Source Type: research
BK virus nephropathy (BKN) is uncommonly reported in native kidneys; mostly reported in bone marrow transplant patients. This case report represents an interesting clinical scenario of biopsy ‐proven BKN in native kidneys, in the presence of more than one million copies/mL of BK virus in serum. Key Clinical MessageBK virus nephropathy (BKN) is uncommonly reported in native kidneys; mostly reported in bone marrow transplant patients. This case report represents an interesting clinical scenario of biopsy ‐proven BKN in native kidneys, in the presence of more than one million copies/mL of BK virus in serum.
Source: Clinical Case Reports - Category: General Medicine Authors: Tags: CASE REPORT Source Type: research
BK virus nephropathy and multiorgan involvement in a child with heart transplantation
. Clin Nephrol. 2018 Dec 11;: Authors: Lee Y, Kim YJ, Cho H Abstract BK virus is a known cause of renal failure in kidney transplant recipients, but there is little data regarding its effect on native kidneys in heart transplant patients. Here, we describe the case of a child who underwent heart transplantation and was later diagnosed with BK virus with multiorgan involvement. This patient was diagnosed with dilated cardiomyopathy at 4 months of age and underwent heart transplantation at the age of 5 years. Before ...
Source: Clinical Nephrology - Category: Urology & Nephrology Authors: Tags: Clin Nephrol Source Type: research
Abstract BK virus is a polyoma virus which remains in latent phase in the urinary tract, particularly in the renal tubular epithelial cells. In immunosuppressed patients, it is activated and manifests as tubule-interstitial nephritis causing renal allograft dysfunction. A total of 402 patients who underwent renal allograft biopsy from 2013 to 2016 were included in this study; six patients were diagnosed to have BK virus nephropathy. Histopathology showed ground glass intra-nuclear inclusions accompanied by acute tubular injury, interstitial inflammation, and varying degree of interstitial fibrosis and tubular atro...
Source: Saudi Journal of Kidney Diseases and Transplantation - Category: Urology & Nephrology Authors: Tags: Saudi J Kidney Dis Transpl Source Type: research
In recent years, BK polyomavirus (BKPyV) infection has emerged as a major problem in kidney transplant recipients. About 90% of the latter are seropositive for BKPyV [1]. The virus reactivates periodically with urinary shedding but remains asymptomatic in immunocompetent adults. The immunosuppressive therapy used to prevent rejection after solid organ transplantation allows viral infections to emerge. In particular, BK virus can reactivate after kidney transplantation, and may induce progressive disease in three successive stages: viruria, viremia, and then (if viral replication persists) nephropathy.
Source: Journal of Clinical Virology - Category: Virology Authors: Source Type: research
This article briefly describes BK virology, epidemiology, diagnosis, and management.
Source: Infectious Diseases Clinics of North America - Category: Infectious Diseases Authors: Source Type: research
We present a series of cases of presumed de novo collapsing FSGS in 5 transplanted kidneys from 3 deceased donors later identified as carrying 2 APOL1 risk alleles, including 2 recipients from the same donor whose kidneys were transplanted in 2 different institutions. Four of these recipients had viremia in the period preceding the diagnosis of collapsing FSGS. Cytomegalovirus and BK virus infection were present in 3 and 1 of our 5 cases, respectively, around the time that collapsing FSGS occurred. We discuss viral infections, including active cytomegalovirus infection, as possible “second hits” that may lead t...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
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