The nematode Caenorhabditis elegans as a model for aging research

Publication date: Available online 6 January 2019Source: Drug Discovery Today: Disease ModelsAuthor(s): Hildegard I.D. Mack, Thomas Heimbucher, Coleen T. MurphyThe nematode Caenorhabditis elegans is a key model system for experimental research on the genetic regulation of aging, and has paved the way towards many important discoveries in this field. Importantly, in the course of its short lifespan of ∼3 weeks, C. elegans displays many phenotypic, behavioral, and molecular changes that are widely shared among metazoans as they age. In this review, we summarize how aging research takes advantage of C. elegans’ biology, and we describe the experimental toolbox available to study worm aging.
Source: Drug Discovery Today: Disease Models - Category: Drugs & Pharmacology Source Type: research