Diastereomerically Pure 6R- and 6S-3'-Aza-2'-18F-Fluoro-5-Methyltetrahydrofolates Show Unprecedentedly High Uptake in Folate Receptor-Positive KB Tumors

Conclusion: We have successfully radiolabeled 6R- and 6S-3'-aza-2'-18F-fluoro-5-MTHF with 18F using the integrated approach. Our results suggest that both 6R- and 6S-3'-aza-2'-18F-fluoro-5-MTHF are promising reduced radiofolates for imaging FR-α–expressing cancers.

Source: Journal of Nuclear Medicine - January 2, 2019 Category: Nuclear Medicine Authors: Boss, S. D., Muller, C., Siwowska, K., Schmid, R. M., Groehn, V., Schibli, R., Ametamey, S. M. Tags: Basic Source Type: research