18F-Flortanidazole Hypoxia PET Holds Promise as a Prognostic and Predictive Imaging Biomarker in a Lung Cancer Xenograft Model Treated with Metformin and Radiotherapy

Conclusion: Using 18F-flortanidazole PET imaging in a non–small cell lung cancer xenograft model, we showed that metformin may act as a radiosensitizer by increasing tumor oxygenation and that baseline 18F-flortanidazole shows promise as an imaging biomarker.

Source: Journal of Nuclear Medicine - January 2, 2019 Category: Nuclear Medicine Authors: De Bruycker, S., Vangestel, C., Van den Wyngaert, T., Pauwels, P., wyffels, L., Staelens, S., Stroobants, S. Tags: Basic Source Type: research