Differentiated Thyroid Cancer Outcomes After Surgery and Activity-Adjusted 131I Theragnostics

Conclusions Detection of regional and distant metastases on postoperative Dx scans permits adjustment of prescribed 131I activity for targeted treatment, as compared with fixed-activity ablation. This approach resulted in complete response after a single 131I treatment in 88% patients with histopathologic risk factors and regional metastases and 42% patients with distant metastases. Most patients with structural incomplete response (81%) had elevated thyroglobulin levels with negative follow-up 131I scans and positive PET/CT and/or CT scans consistent with altered tumor biology (non–iodine-avid disease).
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Original Articles Source Type: research