Abstract 854: Inhibition of PRMT5 results in radiosensitization in lung cancer cell lines
Conclusion: PRMT5 inhibition by siRNA or its specific inhibitors lead to radiosensitivity in A549 lung cancer cell line. This effect may be partially dependent on p53-dependent cell cycle arrest. Further work to inhibit PRMT5 in other lung cancer cell lines with different p53 activities will be investigated.
Citation Format: Smitha Sharma, X Wu, P Smith, N Denko, C Li, H Lai, F Yan, K Shilo, A Chakravarti, S Sif, R Baiocchi, G Otterson, Meng Xu-Welliver. Inhibition of PRMT5 results in radiosensitization in lung cancer cell lines. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 854. doi:10.1158/1538-7445.AM2014-854
Source: Cancer Research - Category: Cancer & Oncology Authors: Sharma, S., Wu, X., Smith, P., Denko, N., Li, C., Lai, H., Yan, F., Shilo, K., Chakravarti, A., Sif, S., Baiocchi, R., Otterson, G., Xu-Welliver, M. Tags: Clinical Research (Excluding Clinical Trials) Source Type: research
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