A single detector energy-resolved proton radiography system: a proof of principle study by Monte Carlo simulations.

In this study, we followed a newly proposed proton beam radiography technique based on energy resolved dose functions (ERDF) to construct a Monte Carlo model for a single detector energy-resolved proton radiography system (SDPRS). This SDPRS model was constructed in the Monte Carlo software package TOPAS (TOol for PArticle Simulation) and it includes the Mevion HYPERSCANTM pencil beam scanning treatment head and a 2D dose detector positioned downstream as the imager. A calibration phantom containing a number of tissue equivalent materials was simulated to evaluate the accuracy in WEPL measurement by SDPRS. The mean deviation of the obtained relative stopping power (RSP) from the reference values was 0.31%. Proton radiographs of an anthropomorphic head phantom were also generated to demonstrate the clinical relevance of the technique. Effects of different energy layer spacing and measurement noise were also studied. PMID: 30561376 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30561376?dopt=Abstract

Source: Physics in Medicine and Biology - December 18, 2018 Category: Physics Authors: Huo W, Zwart T, Cooley JE, Huang K, Finley C, Jee KW, Sharp GC, Rosenthal S, Xu XG, Lu HM Tags: Phys Med Biol Source Type: research