Lung transplantation in two cystic fibrosis patients infected with previously pandrug-resistant Burkholderia cepacia complex treated with ceftazidime –avibactam

We describe two cystic fibrosis patients infected with pandrug-resistantBurkholderia cepacia complex, with the exception of ceftazidime –avibactam, who received prophylaxis with this antibiotic during lung transplantation. Although both patients had a post-operative relapse of respiratory infection, one with positive blood cultures, ceftazidime–avibactam treatment yielded a favourable outcome. 12 months after transplantation, on e patient presented an excellent clinical outcome. However, the other patient died 10 months later due to severeB. cepacia sinusitis with intracranial invasion.
Source: Infection - Category: Infectious Diseases Source Type: research