Multidisciplinary Analysis of Pediatric T-ALL: 9q34 Gene Fusions

T-cell acute lymphoblastic leukemia (T-ALL) is less common than B-cell acute lymphoblastic leukemia (B-ALL) in pediatric as well as adult malignancies, comprising 15% of ALL cases in children and 25% of cases in adults [1]. However, the relative adverse outcome of T-ALL warrants special attention, with many pathogenic gene mutations having been identified. Rapid identification of clone specific subgroups is of primary importance for stratifying responses to treatment, with the ultimate goal of improving cure rates.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Tags: Original Article Source Type: research