Is There an Impact from the FMR1 Gene on In Vitro Fertilization Success?

Publication date: Available online 10 December 2018Source: Reproductive BioMedicine OnlineAuthor(s): Lisa M Pastore, Mindy S Christianson, Bailey McGuinness, Kamaria Cayton Vaught, Jacqueline Y. Maher, William G KearnsABSTRACTWhile it is well known that FMR1 CCG trinucleotide repeat expansions are associated with Fragile X Syndrome (full mutations) and primary ovarian insufficiency (premutation range), the effect of FMR1 on fertility treatment success is less clear. This paper reviews the impact of FMR1 CGG repeat lengths on in vitro fertilization (IVF) outcomes after controlled ovarian hyperstimulation has commenced. PubMed was searched for publications on IVF-related outcomes that were reported with detail by FMR1 trinucleotide repeat length from 2002 through December 2017. For women with CGG repeats in the normal (<45 CGG) and/or intermediate range (45-54 CGG), research to date supports minimal impact on IVF outcomes including pregnancy rates, athough 1 large study reported lower oocyte yields after IVF stimulation in women with lower CGG repeat lengths and normal ovarian reserve. Meta-analysis revealed no association within subcategories of normal repeat length (<45 CGG) and IVF pregnancy rates (summary odds ratio 1.0, 95% CI 0.87-1.15). Premutation carriers (CCG 55-200) may have reduced success with IVF treatment as measured by a lower oocyte yield than women with either a normal CGG repeat length or a full mutation, although there is inconsistency in the finding...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research