Plasma levels of heart failure biomarkers are primarily a reflection of extracardiac production

Conclusions: The Gal-3, GDF-15 and TIMP-1 plasma pool levels are hardly influenced by dynamic changes in cardiac expression. These biomarkers are not specific for indices of cardiac remodeling, but predominantly reflect stress in other affected tissues and hence provide health information beyond the heart.

Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Weijie Du, Arnold Piek, E. Marloes Schouten, Cees W.A. van de Kolk, Christian Mueller, Alexandre Mebazaa, Adriaan A. Voors, Rudolf A. de Boer, Herman H.W. Sillj é Tags: Research Paper Source Type: research