Correlation of imaging and histopathology of thrombi in acute ischemic stroke with etiology and outcome.

This article aims to review the current literature on histopathological composition of acute ischemic stroke clots, with a particular focus on the correlation between clot composition and diagnostic imaging, stroke etiology and revascularization outcomes. PMID: 30514073 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgical Sciences - Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

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Publication date: Available online 23 May 2019Source: The Lancet NeurologyAuthor(s): Duncan Wilson, Gareth Ambler, Keon-Joo Lee, Jae-Sung Lim, Masayuki Shiozawa, Masatoshi Koga, Linxin Li, Caroline Lovelock, Hugues Chabriat, Michael Hennerici, Yuen Kwun Wong, Henry Ka Fung Mak, Luis Prats-Sánchez, Alejandro Martínez-Domeño, Shigeru Inamura, Kazuhisa Yoshifuji, Ethem Murat Arsava, Solveig Horstmann, Jan Purrucker, Bonnie Yin Ka LamSummaryBackgroundCerebral microbleeds are a neuroimaging biomarker of stroke risk. A crucial clinical question is whether cerebral microbleeds indicate patients with recent is...
Source: The Lancet Neurology - Category: Neurology Source Type: research
Publication date: Available online 22 May 2019Source: The Lancet NeurologyAuthor(s): Rustam Al-Shahi Salman, David P Minks, Dipayan Mitra, Mark A Rodrigues, Priya Bhatnagar, Johann C du Plessis, Yogish Joshi, Martin S Dennis, Gordon D Murray, David E Newby, Peter A G Sandercock, Nikola Sprigg, Jacqueline Stephen, Cathie L M Sudlow, David J Werring, William N Whiteley, Joanna M Wardlaw, Philip M White, Colin Baigent, Daniel LassersonSummaryBackgroundFindings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antipl...
Source: The Lancet Neurology - Category: Neurology Source Type: research
Conclusion: Patients with prior stroke may be the preferred group for LAAC regardless of the presence or absence of contraindications for anticoagulant therapy.
Source: Cerebrovascular Diseases - Category: Neurology Source Type: research
Conclusions: We provided an exhaustive overview and real-life professional practices conditions in thrombolyzed AIS. Despite a later prehospital management in neurovascular units and more severe strokes at admission, women and men had both similar outcomes at hospital discharge and in 3-month survival, but women were associated to worst functional outcome at 3 months.Cerebrovasc Dis
Source: Cerebrovascular Diseases - Category: Neurology Source Type: research
CONCLUSIONS: Flow-diverting stents are being used to treat diverse types of aneurysms and in various locations, in distal small caliber vessels where other treatment options pose a considerable risk. Small caliber group had similar complication and occlusion rates compared to proximal vessel group. PMID: 31111723 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgical Sciences - Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research
Publication date: Available online 23 May 2019Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): María M. Adeva-Andany, Raquel Funcasta-Calderón, Carlos Fernández-Fernández, Eva Ameneiros-Rodríguez, Alberto Domínguez-MonteroAbstractPatients with diabetes experience increased cardiovascular risk that is not fully explained by deficient glycemic control or traditional cardiovascular risk factors such as smoking and hypercholesterolemia. Asymptomatic patients with diabetes show structural and functional vascular damage that includes impaired vasodilatio...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
ConclusionsAll results showed that ESL can play a therapeutic role in treating ischemic stroke through different pathways. This study will provide an overall view of the mechanism underlying the action of ESL against ischemic stroke.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
MicroRNA‑22 alleviates inflammation in ischemic stroke via p38 MAPK pathways. Mol Med Rep. 2019 May 22;: Authors: Dong H, Cui B, Hao X Abstract The present study aimed to ascertain the potential roles and mechanisms of action of micro (mi)RNA‑22 in ischemic stroke. The results indicated that miRNA‑22 expression was downregulated in ischemic stroke rats model, compared with a control group. The downregulation of miRNA‑22 upregulated the expression of inflammatory factors [including tumor necrosis factor‑α, interleukin (IL)‑1β, IL‑6 and IL‑18]. It could also induce the expressi...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Conditions:   Stroke;   Cardiovascular Diseases;   Cardiovascular Risk Factor;   Brain Ischemia;   Cerebrovascular Disorders;   Nervous System Diseases;   Central Nervous System Lymphoma;   Pathologic Processes;   Vascular Diseases Intervention:   Other: no intervention Sponsors:   Norwegian University of Science and Technology;   St. Olavs Hospital;   Helse Midt-Norge Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Stroke, Ischemic Interventions:   Drug: Rivaroxaban;   Drug: Dabigatran;   Drug: Apixaban;   Drug: Edoxaban;   Drug: Aspirin;   Drug: Clopidogrel Sponsor:   University of Zurich Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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