Cigarette smoking and heavy coffee consumption affecting response to olanzapine: the role of genetic polymorphism.

CONCLUSIONS: We confirm the effect of cigarette smoking and heavy coffee consumption on olanzapine efficacy and safety. The relevance of CYP1A2 genotype for the described effect needs further investigation. Olanzapine treatment outcome is also affected by dose, sex, age and CYP2D6 metabolizer status. PMID: 30513034 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30513034?dopt=Abstract

Source: The World Journal of Biological Psychiatry - December 4, 2018 Category: Psychiatry Authors: Djordjevic N, Radmanovic B, Cukic J, Baskic D, Djukic-Dejanovic S, Milovanovic D, Aklillu E Tags: World J Biol Psychiatry Source Type: research