Neutrophil-to-lymphocyte ratio: A crucial determinant of reverse remodeling in patients with heart failure undergoing transcatheter aortic valve implantation?

Publication date: Available online 29 October 2018Source: Indian Heart JournalAuthor(s): Kenan YaltaAbstractIn the setting of systolic heart failure (HF), left ventricular reverse remodeling (LVRR) is generally characterized by a gradual and significant improvement in left ventricular (LV) systolic functions, and has been universally regarded as a favorable sign possibly with the highest prognostic benefit in this setting. Importantly, this phenomenon, besides its well known potential to arise spontaneously, is usually more likely to emerge after correction of culprit valvular pathologies including aortic stenosis (AS), etc. Accordingly, interventions including transcatheter aortic valve implantation (TAVI) might have a substantial impact on LVRR evolution in the clinical setting.On the other hand, a proper mileu characterized by low levels of systemic inflammation, on top of mechanical relief of AS, also appears to be necessary for the evolution of LVRR among TAVI recipients. In particular, neutrophil to lymphocyte ratio (NLR), a simple measure of systemic inflammation, might be regarded as a crucial determinant of LVRR arising after TAVI. Accordingly, an existing low NLR value at baseline might serve as a clinical guide for the prediction of LVRR evolution in the post-TAVI setting. However, the potential link between LVRR and NLR (along with their independent prognostic impacts) among TAVI recipients still needs to be fully established through further studies.
Source: Indian Heart Journal - Category: Cardiology Source Type: research